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warfarin sodium tablet
WARFARIN SODIUM TABLETS USP
|CLINICAL STUDIES OF WARFARIN IN NON-RHEUMATIC AF PATIENTS*|
|Study||N||PT Ratio||INR||Thromboembolism||% Major Bleeding|
|Warfarin-||Control||% Risk||p- value||Warfarin-||Control|
*All study results of warfarin vs. control are based on intention-to-treat analysis and include ischemic stroke and systemic thromboembolism, excluding hemorrhage and transient ischemic attacks.
WARIS (The Warfarin Re-Infarction Study) was a double-blind, randomized study of 1214 patients 2 to 4 weeks postinfarction treated with warfarin to a target INR of 2.8 to 4.8. [But note that a lower INR was achieved and increased bleeding was associated with INR's above 4.0; (see DOSAGE AND ADMINISTRATION)]. The primary endpoint was a combination of total mortality and recurrent infarction. A secondary endpoint of cerebrovascular events was assessed. Mean follow-up of the patients was 37 months. The results for each endpoint separately, including an analysis of vascular death, are provided in the following table:
|Total Patient Years of Follow-up||2018||1944|
|Total Mortality||94 (4.7/100 py)||123 (6.3/100 py)||0.76 (0.60, 0.97)||24 (p=0.030)|
|Vascular Death||82 (4.1/100 py)||105 (5.4/100 py)||0.78 (0.60, 1.02)||22 (p=0.068)|
|Recurrent MI||82 (4.1/100 py)||124 (6.4/100 py)||0.66 (0.51, 0.85)||34 (p=0.001)|
|Cerebrovascular Event||20 (1.0/100 py)||44 (2.3/100 py)||0.46 (0.28, 0.75)||54 (p=0.002)|
RR=Relative risk; Risk reduction=(I-RR); CI=Confidence interval; MI=Myocardial infarction; py=patient years
WARIS II (The Warfarin, Aspirin, Re-Infarction Study) was an open-label randomized study of 3630 patients hospitalized for acute myocardial infarction treated with warfarin target INR 2.8 to 4.2, aspirin 160 mg/day, or warfarin target INR 2.0 to 2.5 plus aspirin 75 mg/day prior to hospital discharge. There were approximately four times as many major bleeding episodes in the two groups receiving warfarin than in the group receiving aspirin alone. Major bleeding episodes were not more frequent among patients receiving aspirin plus warfarin than among those receiving warfarin alone, but the incidence of minor bleeding episodes was higher in the combined therapy group. The primary endpoint was a composite of death, nonfatal reinfarction, or thromboembolic stroke. The mean duration of observation was approximately 4 years. The results for WARIS II are provided in the following table1:
|Table 3: WARIS II - Distribution of Separate Events According to Treatment Group*|
|Event||Aspirin||Warfarin||Aspirin Plus Warfarin||Rate Ratio||p-value|
|Thromboembolic stroke||32||17||17||0.52 (0.28-0.98)a||0.03|
|Major Bleeding c||8||33||28||3.35a (ND)||ND|
|Minor Bleeding d||39||103||133||3.21a (ND)||ND|
* CI denotes confidence interval.
a The rate ratio is for aspirin plus warfarin as compared with aspirin.
b The rate ratio is for warfarin as compared with aspirin.
cMajor bleeding episodes were defined as nonfatal cerebral hemorrhage or bleeding necessitating
d Minor bleeding episodes were defined as non-cerebral hemorrhage not necessitating surgical intervention of blood transfusion.
ND =not determined.
MECHANICAL AND BIOPROSTHETIC HEART VALVES
In a prospective, randomized, open label, positive-controlled study2 in 254 patients, the thromboembolic-free interval was found to be significantly greater in patients with mechanical prosthetic heart valves treated with warfarin alone compared with dipyridamole-aspirin (p<0.005) and pentoxifylline-aspirin (p<0.05) treated patients. Rates of hromboembolic events in these groups were 2.2, 8.6, and 7.9/100 patient years, respectively. Major bleeding rates were 2.5, 0.0, and 0.9/100 patient years, respectively.
In a prospective, open label, clinical trial comparing moderate (INR 2.65) vs. high intensity (INR 9.0) warfarin therapies in 258 patients with mechanical prosthetic heart valves, thromboembolism occurred with similar frequency in the two groups (4.0 and 3.7 events/100 patient years, respectively). Major bleeding was more common in the high intensity group (2.1 events/100 patient years) vs. 0.95 events/100 patient years in the moderate intensity group3.
In a randomized trial in 210 patients comparing two intensities of warfarin therapy (INR 2.0 to 2.25 vs. INR 2.5 to 4.0) for a three month period following tissue heart valve replacement, thromboembolism occurred with similar frequency in the two groups (major embolic events 2.0% vs. 1.9%, respectively and minor embolic events 10.8% vs. 10.2%, respectively). Major bleeding complications were more frequent with the higher intensity (major hemorrhages 4.6%) vs. none in the lower intensity4.
Warfarin sodium tablets are indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, and pulmonary embolism.
Warfarin sodium tablets are indicated for the prophylaxis and/or treatment of the thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement.
Warfarin sodium tablets are indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction.
Anticoagulation is contraindicated in any localized or general physical condition or personal circumstance in which the hazard of hemorrhage might be greater than the potential clinical benefits of anticoagulation, such as:
Pregnancy:Warfarin sodium tablets are contraindicated in women who are or may become pregnant because the drug passes through the placental barrier and may cause fatal hemorrhage to the fetus in utero. Furthermore, there have been reports of birth malformations in children born to mothers who have been treated with warfarin during pregnancy.
Embryopathy characterized by nasal hypoplasia with or without stippled epiphyses (chondrodysplasia punctata) has been reported in pregnant women exposed to warfarin during the first trimester. Central nervous system abnormalities also have been reported, including dorsal midline dysplasia characterized by agenesis of the corpus callosum, Dandy-Walker malformation, and midline cerebellar atrophy. Ventral midline dysplasia, characterized by optic atrophy, and eye abnormalities have been observed. Mental retardation, blindness, and other central nervous system abnormalities have been reported in association with second and third trimester exposure. Although rare, teratogenic reports following in utero exposure to warfarin include urinary tract anomalies such as single kidney, asplenia, anencephaly, spina bifida, cranial nerve palsy, hydrocephalus, cardiac defects and congenital heart disease, polydactyly, deformities of toes, diaphragmatic hernia, corneal leukoma, cleft palate, cleft lip, schizencephaly, and microcephaly.
Spontaneous abortion and still birth are known to occur and a higher risk of fetal mortality is associated with the use of warfarin. Low birth weight and growth retardation have also been reported.
Women of childbearing potential who are candidates for anticoagulant therapy should be carefully evaluated and the indications critically reviewed with the patient. If the patient becomes pregnant while taking this drug, she should be apprised of the potential risks to the fetus, and the possibility of termination of the pregnancy should be discussed in light of those risks.
Hemorrhagic tendencies or blood dyscrasias.
Recent or contemplated surgery of: (1) central nervous system; (2) eye; (3) traumatic surgery resulting in large open surfaces.
Bleeding tendencies associated with active ulceration or overt bleeding of: (1) gastrointestinal, genitourinary or respiratory tracts; (2) cerebrovascular hemorrhage; (3) aneurysms-cerebral, dissecting aorta; (4) pericarditis and pericardial effusions; (5) bacterial endocarditis.
Threatened abortion, eclampsia and preeclampsia.
Inadequate laboratory facilities.
Unsupervised patients with senility, alcoholism, or psychosis or other lack of patient cooperation.
Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding.
Miscellaneous: major regional, lumbar block anesthesia, malignant hypertension and known hypersensitivity to warfarin or to any other components of this product.
The most serious risks associated with anticoagulant therapy with warfarin sodium are hemorrhage in any tissue or organ5 (see BLACK BOX WARNING) and, less frequently (<0.1%), necrosis and/or gangrene of skin and other tissues. Hemorrhage and necrosis have in some cases been reported to result in death or permanent disability. Necrosis appears to be associated with local thrombosis and usually appears within a few days of the start of anticoagulant therapy. In severe cases of necrosis, treatment through debridement or amputation of the affected tissue, limb, breast or penis has been reported. Careful diagnosis is required to determine whether necrosis is caused by an underlying disease. Warfarin therapy should be discontinued when warfarin is suspected to be the cause of developing necrosis and heparin therapy may be considered for anticoagulation. Although various treatments have been attempted, no treatment for necrosis has been considered uniformly effective. See below for information on predisposing conditions. These and other risks associated with anticoagulant therapy must be weighed against the risk of thrombosis or embolization in untreated cases.
It cannot be emphasized too strongly that treatment of each patient is a highly individualized matter. Warfarin sodium, a narrow therapeutic range (index) drug, may be affected by factors such as other drugs and dietary Vitamin K. Dosage should be controlled by periodic determinations of prothrombin time (PT)/lnternational Normalized Ratio (INR) or other suitable coagulation tests. Determinations of whole blood clotting and bleeding times are not effective measures for control of therapy. Heparin prolongs the one-stage PT. When heparin and warfarin are administered concomitantly, refer below to CONVERSION FROM HEPARIN THERAPY for recommendations.
Caution should be observed when warfarin sodium is administered in any situation or in the presence of any predisposing condition where added risk of hemorrhage, necrosis, and/or gangrene is present.
Anticoagulation therapy with warfarin sodium may enhance the release of atheromatous plaque emboli, thereby increasing the risk of complications from systemic cholesterol microembolization, including the "purple toes syndrome". Discontinuation of warfarin sodium therapy is recommended when such phenomena are observed. Systemic atheroemboli and cholesterol microemboli can present with a variety of signs and symptoms including purple toes syndrome, livedo reticularis, rash, gangrene, abrupt and intense pain in the leg, foot, or toes, foot ulcers, myalgia, penile gangrene, abdominal pain, flank or back pain, hematuria, renal insufficiency, hypertension, cerebral ischemia, spinal cord infarction, pancreatitis, symptoms simulating polyarteritis, or any other sequelae of vascular compromise due to embolic occlusion. The most commonly involved visceral organs are the kidneys followed by the pancreas, spleen, and liver. Some cases have progressed to necrosis or death.
Purple toes syndrome is a complication of oral anticoagulation characterized by a dark, purplish or mottled color of the toes, usually occurring between 3 to 10 weeks, or later, after the initiation of therapy with warfarin or related compounds. Major features of this syndrome include purple color of plantar surfaces and sides of the toes that blanches on moderate pressure and fades with elevation of the legs; pain and tenderness of the toes; waxing and waning of the color over time. While the purple toes syndrome is reported to be reversible, some cases progress to gangrene or necrosis which may require debridement of the affected area, or may lead to amputation.
Warfarin sodium should be used with caution in patients with heparin-induced thrombocytopenia and deep venous thrombosis. Cases of venous limb ischemia, necrosis, and gangrene have occurred in patients with heparin-induced thrombocytopenia and deep venous thrombosis when heparin treatment was discontinued and warfarin therapy was started or continued. In some patients sequelae have included amputation of the involved area and/or death6.
A severe elevation (>50 seconds) in activated partial thromboplastin time (aPTT) with a PT/INR in the desired range as been identified as an indication of increased risk of postoperative hemorrhage.
The decision to administer anticoagulants in the following conditions must be based upon clinical judgment in which the risks of anticoagulant therapy are weighed against the benefits:
Lactation: Based on very limited published data, warfarin has not been detected in the breast milk of mothers treated with warfarin. The same limited published data reports that some breast-fed infants, whose mothers were treated with warfarin, had prolonged prothrombin times, although not as prolonged as those of the mothers. The decision to breastfeed should be undertaken only after careful consideration of the available alternatives.Women who are breastfeeding and anticoagulated with warfarin should be very carefully monitored so that recommended PT/INR values are not exceeded. It is prudent to perform coagulation tests and to evaluate Vitamin K status in infants at risk for bleeding tendencies before advising women taking warfarin to breast-feed. Effects in premature infants have not been evaluated.
Severe to moderate hepatic or renal insufficiency.
Infectious diseases or disturbances of intestinal flora: sprue, antibiotic therapy.
Trauma which may result in internal bleeding.
Surgery or trauma resulting in large exposed raw surfaces.
Severe to moderate hypertension.
Known or suspected deficiency in protein C mediated anticoagulant response: Hereditary or acquired deficiencies of protein C or its cofactor, protein S, have been associated with tissue necrosis following warfarin administration. Not all patients with these conditions develop necrosis, and tissue necrosis occurs in patients without these deficiencies. Inherited resistance to activated protein C has been described in many patients with venous thromboembolic disorders but has not yet been evaluated as a risk factor for tissue necrosis. The risk associated with these conditions, both for recurrent thrombosis and for adverse reactions, is difficult to evaluate since it does not appear to be the same for everyone. Decisions about testing and therapy must be made on an individual basis. It has been reported that concomitant anticoagulation therapy with heparin for 5 to 7 days during initiation of therapy with warfarin sodium may minimize the incidence of tissue necrosis. Warfarin therapy should be discontinued when warfarin is suspected to be the cause of developing necrosis and heparin therapy may be considered for anticoagulation.
Miscellaneous: polycythemia vera, vasculitis, and severe diabetes.
Minor and severe allergic/hypersensitivity reactions and anaphylactic reactions have been reported.
In patients with acquired or inherited warfarin resistance, decreased therapeutic responses to warfarin sodium have been reported. Exaggerated therapeutic responses have been reported in other patients.
Patients with congestive heart failure may exhibit greater than expected PT/INR response to warfarin sodium, thereby requiring more frequent laboratory monitoring, and reduced doses of warfarin sodium.
Concomitant use of anticoagulants with streptokinase or urokinase is not recommended and may be hazardous. Please note recommendations accompanying these preparations.)
Periodic determination of PT/INR or other suitable coagulation test is essential (see DOSAGE ANDADMINISTRATION: LABORATORY CONTROL).
Numerous factors, alone or in combination, including changes in diet, and medications, includingbotanicals, may influence response of the patient to anticoagulants. It is generally good practice tomonitor the patient’s response with additional PT/INR determinations in the period immediately afterdischarge from the hospital, and whenever other medications, including botanicals, are initiated,discontinued or taken irregularly. The following factors are listed for reference; however, other factors mayalso affect the anticoagulant response.
Drugs may interact with warfarin sodium through pharmacodynamic or pharmacokinetic mechanisms.Pharmacodynamic mechanisms for drug interactions with warfarin sodium are synergism (impaired hemostasis,reduced clotting factor synthesis), competitive antagonism (vitamin K), and altered physiologic controlloop for vitamin K metabolism (hereditary resistance). Pharmacokinetic mechanisms for drug interactionswith warfarin sodium are mainly enzyme induction, enzyme inhibition, and reduced plasma protein binding. It isimportant to note that some drugs may interact by more than one mechanism.
The following factors, alone or in combination, may be responsible for INCREASED PT/INR response:
|blood dyscrasias-||hepatic disorders|
|See CONTRAINDICATIONS||infectious hepatitis|
|collagen vascular disease||hyperthyroidism|
|congestive heart failure||poor nutritional state|
|elevated temperature||vitamin K deficiency|
Potential drug interactions with warfarin sodium are listed below by drug class and by specific drugs.
|Classes of Drugs|
|5-lipoxygenase Inhibitor||Antimalarial Agents||Hypnotics†||Thyroid Drugs|
|Adrenergic Stimulants, Central||Antineoplastics†||Hypolipidemics†||Tuberculosis Agents†|
|Alcohol Abuse Reduction||Antiparasitic/Antimicrobials||Bile Acid-Binding Resins†||Uricosuric Agents|
|Preparations||Antiplatelet Drugs/Effects||Fibric Acid Derivatives||Vaccines|
|Analgesics||Antithyroid Drugs†||HMG-CoA Reductase||Vitamins†|
|Anesthetics, Inhalation||Beta-Adrenergic Blockers||Inhibitors†|
|Antiandrogen||Cholelitholytic Agents||Leukotriene Receptor Antagonist|
|Antiarrhythmics†||Diabetes Agents, Oral||Monoamine Oxidase Inhibitors|
|Aminoglycosides (oral)||Fungal Medications, Intravaginal,||Nonsteroidal Anti-Inflammatory|
|Macrolides||Gastric Acidity and Peptic Ulcer||Proton Pump Inhibitors|
|Penicillins, intravenous, high||Gastrointestinal||Pyrazolones|
|Quinolones (fluoroquinolones)||Ulcerative Colitis Agents||Selective Serotonin Reuptake|
|Sulfonamides, long acting||Gout Treatment Agents||Inhibitors|
|Tetracyclines||Hemorrheologic Agents||Steroids, Adrenocortical†|
|Anticoagulants||Hepatotoxic Drugs||Steroids, Anabolic (17-Alkyl|
|Anticonvulsants†||Hyperglycemic Agents||Testosterone Derivatives)|
|Antidepressants†||Hypertensive Emergency Agents||Thrombolytics|
|Specific Drugs Reported|
|azithromycin||ethacrynic acid||methylsalicylate ointment (topical)||rofecoxib|
|capecitabine||fenofibrate||miconazole, (intravaginal, oral,||simvastatin|
|cholestyramine†||ibuprofen||pantoprazole||tissue plasminogen activator (t-PA)|
|ciprofloxacin||indomethacin||penicillin G, intravenous||tramadol|
|cisapride||influenza virus vaccine||pentoxifylline||trimethoprim/sulfamethoxazole|
also: other medications affecting blood elements which may modify hemostasis
prolonged hot weather
unreliable PT/INR determinations
†lncreased and decreased PT/INR responses have been reported.
The following factors, alone or in combination, may be responsible for DECREASED PT/INR response:
|hereditary coumarin resistance||nephrotic syndrome|
Potential drug interactions with warfarin sodium are listed below by drug class and by specific drugs.
|Classes of Drugs|
|Adrenal Cortical Steroid||Antihistamines||Gastric Acidity and Peptic Ulcer||Oral Contraceptives, Estrogen|
|Antacids||Antipsychotic Medications||Hypnotics†||Selective Estrogen Receptor|
|Antianxiety Agents||Antithyroid Drugs†||Hypolipidemics†||Modulators|
|Antiarrhythmics†||Barbiturates||Bile Acid-Binding Resins†||Steroids, Adrenocortical†|
|Antibiotics†||Diuretics†||HMG-CoA Reductase||Tuberculosis Agents†|
|Anticonvulsants†||Enteral Nutritional Supplements||Inhibitors†||Vitamins†|
|Antidepressants†||Fungal Medications, Systemic†||Immunosuppressives|
|Specific Drugs Reported|
|chloral hydrate†||griseofulvin||pravastatin†||vitamin C (high dose)|
also: diet high in vitamin K
unreliable PT/INR determinations
†Increased and decreased PT/INR responses have been reported.
Because a patient may be exposed to a combination of the above factors, the net effect of warfarin sodium on PT/INR response may be unpredictable. More frequent PT/ INR monitoring is therefore advisable. Medications of unknown interaction with coumarins are best regarded with caution. When these medications are started or stopped, more frequent PT/INR monitoring is advisable.
It has been reported that concomitant administration of warfarin and ticlopidine may be associated with cholestatic hepatitis.
Botanical (Herbal) Medicines: Caution should be exercised when botanical medicines (botanicals) are taken concomitantly with warfarin sodium. Few adequate, well-controlled studies exist evaluating the potential for metabolic and/or pharmacologic interactions between botanicals and warfarin sodium. Due to a lack of manufacturing standardization with botanical medicinal preparations, the amount of active ingredients may vary. This could further confound the ability to assess potential interactions and effects on anticoagulation. It is good practice to monitor the patient’s response with additional PT/INR determinations when initiating or discontinuing botanicals.
Specific botanicals reported to affect warfarin sodium therapy include the following:
• Bromelains, danshen, dong quai (Angelica sinensis), garlic, Ginkgo biloba, ginseng, and cranberry products are associated most often with an INCREASE in the effects of warfarin sodium.
• Coenzyme Q10 (ubidecarenone) and St. John’s wort are associated most often with a DECREASE in the effects of warfarin sodium.
Some botanicals may cause bleeding events when taken alone (e.g., garlic and Ginkgo biloba) and may have anticoagulant, antiplatelet, and/or fibrinolytic properties. These effects would be expected to be additive to the anticoagulant effects of warfarin sodium. Conversely, other botanicals may have coagulant properties when taken alone or may decrease the effects of warfarin sodium.
Some botanicals that may affect coagulation are listed below for reference; however, this list should not be considered all-inclusive. Many botanicals have several common names and scientific names. The most widely recoginized common botanical names are listed.
|Botanicals that contain coumarins with potential anticoagulant effects:|
Angelica (Dong Quai)
(German and Roman)
Prickly Ash (Northern)
Wild CarrotWild Lettuce
|Miscellaneous botanicals with anticoagulant properties:|
|Bladder Wrack (Fucus)||Pau d’arco|
|Botanicals that contain salicylate and/or have antiplatelet properties|
|Botanicals with fibrinolytic proper|
|Botanicals with coagultant properties|
1Contains coumarins and salicylate.
2Contains coumarins and has fibrinolytic properties.
3Contains coumarins and has antiplatelet properties.
4Contains salicylate and has coagulant properties.
5Has antiplatelet and fibrinolytic properties.
Coumarins may also affect the action of other drugs. Hypoglycemic agents (chlorpropamide and tolbutamide) and anticonvulsants (phenytoin and phenobarbital) may accumulate in the body as a result of interference with either their metabolism or excretion.
Warfarin sodium is a narrow therapeutic range (index) drug, and caution should be observed when warfarin sodium is administered to certain patients such as the elderly or debilitated or when administered in any situation or physical condition where added risk of hemorrhage is present.
Intramuscular (I.M.) injections of concomitant medications should be confined to the upper extremities which permits easy access for manual compression, inspections for bleeding and use of pressure bandages.
Caution should be observed when warfarin sodium is administered concomitantly with nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, to be certain that no change in anticoagulation dosage is required. In addition to specific drug interactions that might affect PT/INR, NSAIDs, including aspirin, can inhibit platelet aggregation, and can cause gastrointestinal bleeding, peptic ulceration and/or perforation.
Acquired or inherited warfarin resistance should be suspected if large daily doses of warfarin sodium are required to maintain a patient’s PT/INR within a normal therapeutic range.
The objective of anticoagulant therapy is to decrease the clotting ability of the blood so that thrombosis is prevented, while avoiding spontaneous bleeding. Effective therapeutic levels with minimal complications are in part dependent upon cooperative and well-instructed patients who communicate effectively with their physician. Patients should be advised: Strict adherence to prescribed dosage schedule is necessary. Do not take or discontinue any other medication, including salicylates (e.g., aspirin and topical analgesics), other over-the-counter medications, and botanical (herbal) products (e.g., bromelains, coenzyme Q10, danshen, dong quai, garlic, Gingko biloba, ginseng, and St. John’s wort) except on advice of the physician. Avoid alcohol consumption. Do not take warfarin sodium during pregnancy and do not become pregnant while taking it (see CONTRAINDICATIONS). Avoid any activity or sport that may result in traumatic injury. Prothrombin time tests and regular visits to physician or clinic are needed to monitor therapy. Carry identification stating that warfarin sodium is being taken. If the prescribed dose of warfarin sodium is forgotten, notify the physician immediately. Take the dose as soon as possible on the same day but do not take a double dose of warfarin sodium the next day to make up for missed doses. The amount of vitamin K in food may affect therapy with warfarin sodium. Eat a normal, balanced diet maintaining a consistent amount of vitamin K. Avoid drastic changes in dietary habits, such as eating large amounts of green leafy vegetables. You should also avoid intake of cranberry juice or any other cranberry products. Notify your health care provider if any of these products are part of your normal diet. Contact physician to report any illness, such as diarrhea, infection or fever. Notify physician immediately if any unusual bleeding or symptoms occur. Signs and symptoms of bleeding include: pain, swelling or discomfort, prolonged bleeding from cuts, increased menstrual flow or vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or dark brown urine, red or tar black stools, headache, dizziness, or weakness. If therapy with warfarin sodium is discontinued, patients should be cautioned that the anticoagulant effects of warfarin sodium may persist for about 2 to 5 days. Patients should be informed that all warfarin sodium, USP, products represent the same medication,and should not be taken concomitantly, as overdosage may result. A Medication Guide7 should be available to patients when their prescriptions for warfarin sodium are issued.
Carcinogenicity and mutagenicity studies have not been performed with warfarin sodium. The reproductive effects of warfarin sodium have not been evaluated.
Safety and effectiveness in pediatric patients below the age of 18 have not been established, in randomized, controlled clinical trials. However, the use of warfarin sodium in pediatric patients is well-documented for the prevention and treatment of thromboembolic events. Difficulty achieving and maintaining therapeutic PT/INR ranges in the pediatric patient has been reported. More frequent PT/INR determinations are recommended because of possible changing warfarin requirements.
Patients 60 years or older appear to exhibit greater than expected PT/INR response to the anticoagulant effects of warfarin (see CLINICAL PHARMACOLOGY). Warfarin sodium is contraindicated in any unsupervised patient with senility. Caution should be observed with administration of warfarin sodium to elderly patients in any situation or physical condition where added risk of hemorrhage is present. Lower initiation and maintenance doses of warfarin are recommended for elderly patients (see DOSAGE AND ADMINISTRATION).
Potential adverse reactions to warfarin sodium may include:
Rare events of tracheal or tracheobronchial calcification have been reported in association with long-term warfarin therapy. The clinical significance of this event is unknown.
Priapism has been associated with anticoagulant administration, however, a causal relationship has not been established.
Suspected or overt abnormal bleeding (e.g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries) are early manifestations of anticoagulation beyond a safe and satisfactory level.
Excessive anticoagulation, with or without bleeding, may be controlled by discontinuing warfarin sodium therapy and if necessary, by administration of oral or parenteral vitamin K1. (Please see recommendations accompanying vitamin K1 preparations prior to use).8,9
Such use of vitamin K1 reduces response to subsequent warfarin sodium therapy. Patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged PT/INR. Resumption of warfarin sodium administration reverses the effect of vitamin K, and a therapeutic PT/INR can again be obtained by careful dosage adjustment. If rapid anticoagulation is indicated, heparin may be preferable for initial therapy.
If minor bleeding progresses to major bleeding, give 5 to 25 mg (rarely up to 50 mg) parenteral vitamin K1. In emergency situations of severe hemorrhage, clotting factors can be returned to normal by administering 200 to 500 mL of fresh whole blood or fresh frozen plasma, or by giving commercial Factor IX complex.
A risk of hepatitis and other viral diseases is associated with the use of these blood products; Factor IX complex is also associated with an increased risk of thrombosis. Therefore, these preparations should be used only in exceptional or life-threatening bleeding episodes secondary to warfarin sodium overdosage.
Purified Factor IX preparations should not be used because they cannot increase the levels of prothrombin, Factor VII and Factor X which are also depressed along with the levels of Factor IX as a result of warfarin sodium treatment. Packed red blood cells may also be given if significant blood loss has occurred. Infusions of blood or plasma should be monitored carefully to avoid precipitating pulmonary edema in elderly patients or patients with heart disease.
The dosage and administration of warfarin sodium must be individualized for each patient according to the particular patient’s PT/INR response to the drug. The dosage should be adjusted based upon the patient’s PT/INR.8,9,10,11,12The bestavailable information supports the following recommendations for dosing of WARFARIN SODIUM.
For patients with a first episode of DVT or PE secondary to a transient (reversible) risk factor, treatment with warfarin for 3 months is recommended. For patients with a first episode of idiopathic DVT or PE, warfarin is recommended for at least 6 to 12 months. For patients with two or more episodes of documented DVT or PE, indefinite treatment with warfarin is suggested. For patients with a first episode of DVT or PE who have documented antiphospholipid antibodies or who have two or more thrombophilic conditions, treatment for 12 months is recommended and indefinite therapy is suggested. For patients with a first episode of DVT or PE who have documented deficiency of antithrombin, deficiency of Protein C or Protein S, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels (>90th percentile of normal), treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis. The risk-benefit should be reassessed periodically in patients who receive indefinite anticoagulant treatment.5,13 The dose of warfarin should be adjusted to maintain a target INR of 2.5 (INR range, 2.0 to 3.0) for all treatment durations. These recommendations are supported by the 7th ACCP guidelines.8,10,14,15
Five recent clinical trials evaluated the effects of warfarin in patients with non-valvular atrial fibrillation (AF). Meta analysis findings of these studies revealed that the effects of warfarin in reducing thromboembolic events including stroke were similar at either moderately high INR (2.0 to 4.5) or low INR (1.4 to 3.0). There was a significant reduction in minor bleeds at the low INR. There are no adequate and well controlled studies in populations with atrial fibrillation and valvular heart disease. Similar data from clinical studies in valvular atrial fibrillation patients are not available. The trials in non-valvular atrial fibrillation support the American College of Chest Physicians' (7th ACCP) recommendation that an INR of 2.0 to 3.0 be used for warfarin therapy in appropriate AF patients10.
Oral anticoagulation therapy with warfarin is recommended in patients with persistent or paroxysmal AF (PAF) (intermittent AF) at high risk of stroke (i.e., having any of the following features: prior ischemic stroke, transient ischemic attack, or systemic embolism, age >75 years, moderately or severely impaired left ventricular systolic function and/or congestive heart failure, history of hypertension, or diabetes mellitus). In patients with persistent AF or PAF, age 65 to 75 years, in the absence of other risk factors, but who are at intermediate risk of stroke, antithrombotic therapy with either oral warfarin or aspirin, 325 mg/day, is recommended. For patients with AF and mitral stenosis, anticoagulation with oral warfarin is recommended (7th ACCP). For patients with AF and prosthetic heart valves, anticoagulation with oral warfarin should be used; the target INR may be increased and aspirin added depending on valve type and position, and on patient factors.10
The results of the WARIS II study and 7th ACCP guidelines suggest that in most healthcare settings, moderate- and lowrisk patients with a myocardial infarction should be treated with aspirin alone over oral vitamin-K antagonist (VKA) therapy plus aspirin. In healthcare settings in which meticulous INR monitoring is standard and routinely accessible, for both high- and low-risk patients after myocardial infarction (MI), long-term (up to 4 years) high-intensity oral warfarin (target INR, 3.5; range, 3.0 to 4.0) without concomitant aspirin or moderate-intensity oral warfarin (target INR, 2.5; range, 2.0 to 3.0) with aspirin is recommended. For high-risk patients with MI, including those with large anterior MI, those with significant heart failure, those with intracardiac thrombus visible on echocardiography, and those with a history of a thromboembolic event, therapy with combined moderate-intensity (INR, 2.0 to 3.0) oral warfarin plus low-dose aspirin (≤100mg/day) for 3 months after the MI is suggested.16
For all patients with mechanical prosthetic heart valves, warfarin is recommended. For patients with a St. Jude Medical (St. Paul, MN) bileaflet valve in the aortic position, a target INR of 2.5 (range, 2.0 to 3.0) is recommended. For patients with tilting disk valves and bilealet mechanical valves in the mitral position, the 7th ACCP recommends a target INR of 3.0 (range, 2.5 to 3.5). For patients with caged ball or caged disk valves, a target INR of 3.0 (range, 2.5 to 3.5) in combination with aspirin, 75 to 100 mg/day is recommended. For patients with bioprosthetic valves, warfarin therapy with a target INR of 2.5 (range, 2.0 to 3.0) is recommended for valves in the mitral position and is suggested for valves in the aortic position for the first 3 months after valve insertion.8
Oral anticoagulation therapy has not been evaluated by properly designed clinical trials in patients with valvular disease associated with atrial fibrillation, patients with mitral stenosis, and patients with recurrent systemic embolism of unknown etiology. A moderate dose regimen (INR 2.0 to 3.0) is recommended for these patients.10
An INR of greater than 4.0 appears to provide no additional therapeutic benefit in most patients and isassociated with a higher risk of bleeding.
The dosing of warfarin sodium must be individualized according to patient’s sensitivity to the drug as indicated by the PT/INR. Use of a large loading dose may increase the incidence of hemorrhagic and other complications, does not offer more rapid protection against thrombi formation, and is not recommended. Lower initiation and maintenance doses are recommended for elderly and/or debilitated patients and patients with potential to exhibit greater than expected PT/INR response to warfarin sodium (see PRECAUTIONS). Based on limited data, Asian patients may also require lower initiation and maintenance doses of warfarin sodium (see CLINICAL PHARMACOLOGY). It is recommended that warfarin sodium therapy be initiated with a dose of 2 to 5 mg per day with dosage adjustments based on the results of PT/INR determinations.10,11
Most patients are satisfactorily maintained at a dose of 2 to 10 mg daily. Flexibility of dosage is provided by breaking scored tablets in half. The individual dose and interval should be gauged by the patient’s prothrombin response.
The duration of therapy in each patient should be individualized. In general, anticoagulant therapy should be continued until the danger of thrombosis and embolism has passed.7,8,10,11,14,15
The anticoagulant effect of warfarin sodium persists beyond 24 hours. If the patient forgets to take the prescribed dose of warfarin sodium at the scheduled time, the dose should be taken as soon as possible on the same day. The patient should not take the missed dose by doubling the daily dose to make up for missed doses, but should refer back to his or her physician.
Warfarin sodium for injection provides an alternate administration route for patients who cannot receive oral drugs. The IV osage would be the same as those that would be used orally if the patient could take the drug by oral route.
LABORATORY CONTROL: The PT reflects the depression of vitamin K dependent Factors VII, X and II. A system of standardizing the PT in oral anticoagulant control was introduced by the World Health Organization in 1983. It is based upon the determination of an International Normalized Ratio (INR) which provides a common basis for communication of PT results and interpretations of therapeutic ranges.17 The PT should be determined daily after the administration of the initial dose until PT/INR results stabilize in the therapeutic range. Intervals between subsequent PT/INR determinations should be based upon the physician’s judgment of the patient's reliability and response to warfarin sodium in order to maintain the individual within the therapeutic range. Acceptable intervals for PT/INR determinations are normally within the range of one to four weeks after a stable dosage has been determined. To ensure adequate control, it is recommended that additional PT tests be done when other warfarin products are interchanged with warfarin sodium tablets, USP, as well as whenever other medications are initiated, discontinued, or taken irregularly (see PRECAUTIONS). Safety and efficacy of warfarin therapy can be improved by increasing the quality of laboratory control. Reports suggest that in usual care monitoring, patients are in therapeutic range only 33%-64% of the time. Time in therapeutic range is significantly greater (56%-93%) in patients managed by anticoagulation clinics, among self-testing and self-monitoring patients, and in patients managed with the help of computer programs.18 Self-testing patients had fewer bleeding events than patients in usual care.18
TREATMENT DURING DENTISTRY AND SURGERY: The management of patients who undergo dental and surgical procedures requires close liaison between attending physicians, surgeons and dentists.8,12 PT/INR determination is recommended just prior to any dental or surgical procedure. In patients undergoing minimal invasive procedures who must be anticoagulated prior to, during, or immediately following these procedures, adjusting the dosage of warfarin sodium to maintain the PT /INR at the low end of the therapeutic range may safely allow for continued anticoagulation. The operative site should be sufficiently limited and accessible to permit the effective use of local procedures for hemostasis. Under these conditions, dental and minor surgical procedures may be performed without undue risk of hemorrhage. Some dental or surgical procedures may necessitate the interruption of warfarin sodium therapy. When discontinuing warfarin sodium even for a short period of time, the benefits and risks should be strongly considered.
CONVERSION FROM HEPARIN THERAPY: Since the anticoagulant effect of warfarin sodium is delayed, heparin is preferred initially for rapid anticoagulation. Conversion to warfarin sodium may begin concomitantly with heparin therapy or may be delayed 3 to 6 days. To ensure continuous anticoagulation, it is advisable to continue full dose heparin therapy and that warfarin sodium therapy be overlapped with heparin for 4 to 5 days, until warfarin has produced the desired therapeutic response as determined by PT/INR. When warfarin sodium has produced the desired PT/INR or prothrombin activity, heparin may be discontinued.
Warfarin sodium may increase the aPTT test, even in the absence of heparin. During initial therapy with warfarin sodium, the interference with heparin anticoagulation is of minimal clinical significance.
As heparin may affect the PT/INR, patients receiving both heparin and warfarin sodium should have blood for PT/INR determination drawn at least:
• 5 hours after the last IV bolus dose of heparin, or
• 4 hours after cessation of a continuous IV infusion of heparin, or
• 24 hours after the last subcutaneous heparin injection.
Warfarin sodium tablets USP are available as follows:
1 mg: (dark pink, round, flat-faced, beveled-edged tablets with "WF" scoreline "1" on one side and "G" on theother side)
bottles of 100 NDC 15330-100-01
bottles of 1000 NDC 15330-100-10
2 mg: (lavender, round, flat-faced, beveled-edged tablets with "WF" scoreline "2" on one side and "G" on the other side)
bottles of 100 NDC 15330-101-01
bottles of 1000 NDC 15330-101-10
2.5 mg: (green, round, flat-faced, beveled-edged tablets with "WF" scoreline "2.5" on one side and "G" on the other side)
bottles of 100 NDC 15330-102-01
bottles of 1000 NDC 15330-102-10
3 mg: (brown, round, flat-faced, beveled-edged tablets with "WF" scoreline "3" on one side and "G" on the other side)
bottles of 100 NDC 15330-266-01
4 mg: (blue, round, flat-faced, beveled-edged tablets with "WF" scoreline "4" on one side and
"G" on the other side)
bottles of 100 NDC 15330-267-01
5 mg: (peach, round, flat-faced, beveled-edged tablets with "WF" scoreline "5" on one side and
"G" on the other side)
bottles of 100 NDC 15330-268-01
bottles of 1000 NDC 15330-268-10
6 mg: (dark green, round, flat-faced, beveled-edged tablets with "WF" scoreline "6" on one side
and "G" on the other side)
bottles of 100 NDC 15330-106-01
7.5 mg: (yellow, round, flat-faced, beveled-edged tablets with "WF" scoreline "7.5" on one side
and "G" on the other side)
bottles of 100 NDC 15330-107-01
10 mg: (white, round, flat-faced, beveled-edged tablets with "WF" scoreline "10" on one side and
"G" on the other side)
bottles of 100 NDC 15330-108-01
Protect from light. Store at controlled room temperature (59°-86°F, 15°-30°C).
Dispense in a tight, light-resistant container as defined in the USP.
1. Hurlen M, Abdelnoor M, Smith P, Erikssen J, Arnesen H. Warfarin, aspirin, or both after myocardial infarction. N Engl J Med. 2002;347:969-974.
2. Mok CK, Boey J,Wang R, et al.Warfarin versus dipyridamole-aspirin and pentoxifylline-aspirin for prevention of prosthetic valve thromboembolism: a prospective randomized clinical trial. Circ. 1985;72:1059-1063.
3. Saour JN, Sieck JO, Mamo LA, Gallus AS. Trial of different intensities of anticoagulation in patients with prosthetic heart valves. N Engl J Med. 1990;322:428-432.
4. Turpie AG, Hirsh J, Gunstensen J, Nelson H, Gent M. Randomized comparison to two intensities of oral anticoagulant therapy after tissue heart valve replacement. Lancet . 1988;331:1242-1245.
5. Büller HR, Agnelli G, Hull RD, Hyers TM, Prins MH, Raskob GE. Antithrombotic therapy for venous thromboembolic disease. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest . 2004;126:401S-428S.
6. Warkentin TE, Elavathil LJ, Hayward CPM, Johnston MG, Russett JI, Kelton JG. The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytopenia. Ann Intern Med. 1997;127:804-812.
7. COUMADIN Medication Guide. Princeton, NJ: Bristol-Myers Squibb Company; 2006.
8. Salem DN, Stein PD, Al-Ahmad A, et al. Antithrombotic therapy in valvular heart disease–native and prosthetic. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest . 2004;126:457S-482S.
9. American Geriatrics Society Clinical Practice Guidelines. The use of oral anticoagulants (warfarin) in older people. J Amer Geriatr Soc. 2000;48:224-227.
10. Singer DE, Albers GW, Dalen JE, Go AS, Halperin JL, Manning WJ. Antithrombotic therapy in atrial fibrillation. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest . 2004;126:429S-456S.
11. Jaffer AK, Bragg L. Practical tips for warfarin dosing and monitoring. Cleveland Clinic J Med. 2003;70:361-371.
12. Jaffer AK, Brotman DJ, Chukwumerije N. When patients on warfarin need surgery. Cleveland Clinic J Med. 2003;70:973-984.
13. Kearon C, Ginsberg JS, Kovacs MJ, et al, for the Extended Low-Intensity Anticoagulation for Thrombo-Embolism Investigators. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med. 2003;349:631-639.
14. Schulman S, Granqvist S, Holmström M, et al, and the Duration of Anticoagulation Trial Study Group. The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. N Engl J Med.1997;336:393-398.
15. Ridker PM, Goldhaber SZ, Danielson E, et al, for the PREVENT Investigators. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med. 2003;348:1425-1434.
16. Harrington RA, Becker RC, Ezekowitz M, et al. Antithrombotic therapy for coronary artery disease. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest . 2004;126:513S-548S.
17. Ansell J, Hirsh J, Pollen L, Bussey H, Jacobson A, Hylek E. The pharmacology and management of the vitamin K antagonists. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest . 2004;126:204S-233S.
18. Heneghan C, Alonso-Coello P, Garcia-Alamino JM, Perera R, Meats E, Glasziou P. Self-monitoring of oral anticoagulation: a systematic review and meta-analysis. Lancet . 2006;367:404-411.
Napa, CA 94558
Mississauga, ON L5T 1T5
Printed in Canada
012-140 REV.#02 Issue date: November 2006
Read this Medication Guide before you start taking WARFARIN (Warfarin Sodium) and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment. You and your healthcare provider should talk about WARFARIN when you start taking it and at regular checkups.
What is the most important information I should know about WARFARIN?
•Take your WARFARIN exactly as prescribed to lower the chance of bloodclots forming in your body. (See “What is WARFARIN?”).
•WARFARIN is very important for your health, but it can cause serious and life-threatening bleeding problems. To benefit from WARFARIN and also lower your chance for bleeding problems, you must:
•Get your regular blood test to check for your response to WARFARIN.
This blood test is called a PT/INR test. The PT/INR test checks to see how fast your blood clots. Your healthcare provider will decide what PT/INR numbers are best for you. Your dose of WARFARIN will be adjusted to keep your PT/INR in a target range for you.
•Call your healthcare provider right away if you get any of the following
signs or symptoms of bleeding problems:
• pain, swelling or discomfort
• headaches, dizziness, or weakness
• unusual bruising (bruises that develop without known cause or grow in size)
• nose bleeds
• bleeding gums
• bleeding from cuts takes a long time to stop
• menstrual bleeding or vaginal bleeding that is heavier than normal
• pink or brown urine
• red or black stools
• coughing up blood
• vomiting blood or material that looks like coffee grounds
•Many other medicines, including prescription and non-prescription
medicines, vitamins and herbal supplements can interact with WARFARIN
•affect the dose you need, or
•increase WARFARIN side effects.
Tell your healthcare provider about all the medicines you take. Do not stopmedicines or take anything new unless you have talked to your healthcareprovider. Keep a list of your medicines with you at all times to show yourhealthcare provider and pharmacist.
• Do not take other medicines that contain warfarin. Warfarin is the activeingredient in WARFARIN.
•Some foods can interact with WARFARIN and affect your treatment anddose.
•Eat a normal, balanced diet. Talk to your doctor before you make any diet changes. Do not eat large amounts of leafy green vegetables. Leafy green vegetables contain Vitamin K. Certain vegetable oils also contain large amounts of Vitamin K. Too much Vitamin K can lower the effect of WARFARIN.
•Avoid drinking cranberry juice or eating cranberry products.
•Avoid drinking alcohol.
•Always tell all of your healthcare providers that you take WARFARIN.
•Wear or carry information that you take WARFARIN.
WARFARIN is an anticoagulant medicine. It is used to lower the chance of blood clots forming in your body. Blood clots can cause a stroke, heart attack, or other serious conditions such as blood clots in the legs or lungs.
Do not take WARFARIN if:
•your chance of having bleeding problems is higher than the possible
benefit of treatment.
Your healthcare provider will decide if WARFARIN is right for you.
Talk to your healthcare provider about all of your health conditions.
•you are pregnant or plan to become pregnant.
WARFARIN can cause death or birth defects to an unborn baby. Use
effective birth control if you can get pregnant.
•you are allergic to warfarin or to anything else in WARFARIN.
What should I tell my healthcare provider before starting WARFARIN?
Tell your healthcare provider about all of your health conditions, including ifyou:
•have bleeding problems
•have liver or kidney problems
•have high blood pressure
•have a heart problem called congestive heart failure
•drink alcohol or have problems with alcohol abuse. Alcohol can affect your WARFARIN dose and should be avoided.
•are pregnant or planning to become pregnant. See “Who should not
•are breastfeeding. WARFARIN may increase bleeding in your baby. Talk to your doctor about the best way to feed your baby. If you choose to breastfeed while taking WARFARIN, both you and your baby should be carefully monitored for bleeding problems.
Tell your healthcare provider about all the medicines you take includingprescription and non-prescription medicines, vitamins, and herbalsupplements. See “What is the most important information I should knowabout WARFARIN?”
•Take WARFARIN exactly as prescribed. Your healthcare provider will adjust your dose from time to time depending on your response to WARFARIN.
•You must have regular blood tests and visits with your healthcare provider to monitor your condition.
•Take WARFARIN at the same time every day. You can take WARFARIN either with food or on an empty stomach.
•If you miss a dose of WARFARIN, call your healthcare provider. Take the dose as soon as possible on the same day. Do not take a double dose of WARFARIN the next day to make up for a missed dose.
•Call your healthcare provider right away if you take too much WARFARIN.
•Call your healthcare provider if you are sick with diarrhea, an infection, or have a fever.
•Tell your healthcare provider about any planned surgeries, medical or dental procedures. Your WARFARIN may have to be stopped for a short time or you may need your dose adjusted.
•Call your healthcare provider right away if you fall or injure yourself,especially if you hit your head. Your healthcare provider may need to check you.
• Do not start, stop, or change any medicine without talking with your healthcare provider.
• Do not make changes in your diet, such as eating large amounts of green, leafy vegetables.
• Do not change your weight by dieting, without first checking with your
• Avoid drinking alcohol.
• Do not do any activity or sport that may cause a serious injury.
• WARFARIN is very important for your health, but it can cause serious and lifethreatening bleeding problems. See “What is the most important information
I should know about WARFARIN?”
•Serious side effects of WARFARIN also include:
•death of skin tissue (skin necrosis or gangrene). This can happen soon after starting WARFARIN. It happens because blood clots form and block blood flow to an area of your body. Call your healthcare provider right away if you have pain, color, or temperature change to any area of your body. You may need medical care right away to prevent death or loss (amputation) of your affected body part.
•“purple toes syndrome.”Call your healthcare provider right away if you
have pain in your toes and they look purple in color or dark in color.
Other side effects with WARFARIN include allergic reactions, liver problems, low blood pressure, swelling, low red blood cells, paleness, fever, and rash. Call your healthcare provider if you have any side effect that bothers you.
These are not all of the side effects of WARFARIN. For more information, ask your healthcare provider or pharmacist.
• Store WARFARIN at room temperature between 59° and 86° F. Protect from light.
•Keep WARFARIN and all medicines out of the reach of children.
Medicines are sometimes prescribed for purposes not mentioned in a Medication Guide. Do not use WARFARIN for a condition for which it was not prescribed. Do not give WARFARIN to other people, even if they have the same condition. It may harm them.
This Medication Guide summarizes the most important information about WARFARIN. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about WARFARIN that was written for healthcare professionals.
If you would like more information, call
WARFARIN is distributed by:
Napa, CA 94558
This Medication Guide has been approved by the U.S. Food and Drug Administration.
This leaflet was prepared by:
85 Advance Road
Etobicoke, OntarioM8Z 2S6
Issue date: November 2006
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
warfarin sodium tablet
Revised: 01/2007 Genpharm, L.P.
Reproduced with permission of U.S. National Library of Medicine
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