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methylene blue injection, solution
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----------METHYLENE BLUE 10MG/ML
Methylene Blue Injection, USP is a sterile solution of Phenothiazin_5_ium, 3, 7-bis (dimethylamino)- chloride, trihydrate. Each mL contains Methylene Blue, USP, 10 mg in Water for Injection q.s. pH adjusted with Hydrochloric Acid and /or Sodium Hydroxide when necessary.
The structural formula is:
Methylene Blue is Phenothiazin-5ium, 3, 7-bis (dimethylamino)-, chloride, trihydrate. It will produce two opposite actions on hemoglobin. Low concentrations will convert methemoglobin to hemoglobin. High concentrations convert the ferrous iron of reduced hemoglobin to ferric iron which results in the formation of methemoglobin.
Methylene Blue must be injected intravenously very slowly over a period of several minutes to prevent local high concentration of the compound from producing additional methemoglobin.
Do not exceed recommended dosage.
Large intravenous doses of Methylene Blue produce nausea, abdominal and precordial pain, dizziness, headache, profuse sweating, mental confusion and the formation of methemoglobin.
USE IN PREGNANCY
Safety for use in pregnancy has not been established. Use of Methylene Blue in women of childbearing potential requires that anticipated benefits be weighed against possible hazards.
DOSAGE AND ADMINISTRATION
0.1 to 0.2 mL per kg body weight (0.045 to 0.09 mL per pound body weight). Inject Methylene Blue intravenously very slowly over a period of several minutes.
Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.
Store at 20 degrees-25 degrees C (68 degress-77 degrees F); excursions permitted to 15 degrees-30 degrees C (59 degrees-86 degrees F) (See USP Controlled Room Temperature).
Revised: 01/2011 General Injectables & Vaccines, Inc.
Reproduced with permission of U.S. National Library of Medicine
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