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----------AquacalmTM (Metomidate hydrochloride) For immersion use in ornamental finfish only. Not for use in fish intended for human or animal consumption. NOT APPROVED BY FDA – Legally marketed as an FDA indexed product under MIF 900-002. Extra-label use is prohibited.
Each gram of AquacalmTM powder contains 1 gm of metomidate hydrochloride. AquacalmTM acts on the central nervous system to induce sedation or anesthesia in fish immersed in water containing the drug.
For the sedation and anesthesia of ornamental finfish. AquacalmTM is not for use in fish intended for human or animal consumption. Sedation may be necessary in
DIRECTIONS FOR USEAquacalmTM is packaged as a dry powder and must be mixed with water to be used. Determine the amount of AquacalmTM powder needed to achieve the desired concentration for the intended use. Dissolve AquacalmTM in a known volume of water, mix well, and aerate water during sedation or anesthesia. Lightly sedated fish may lose their ability to maintain upright position or position in a stream flow. Deeply sedated or anesthetized fish will experience total loss of equilibrium. Before beginning sedation or anesthesia, ensure that AquacalmTM-free water is available for recovery. Always test the dosage on a small group of fish first to make sure no unintended or adverse effects occur.
AquacalmTM has been tested on representative ornamental finfish species, but has not been tested on all fish species. The effect of AquacalmTM may vary between (and within) species, depending upon age and physical condition of fish, and under different water conditions. Sedate or anesthetize fish in water with temperature and pH close to the temperature and pH of the rearing water.
Caution should be taken when using this product on/for:
1. Larval fish species, which may be more sensitive to sedation than older fish of the same species
2. Fish species such as knifefish and gouramis
3. Any fish species for extended periods (e.g.> 24 hr) used during transportation
Dose for sedation: 0.1 to 1.0 mg/L
Dose for anesthesia: 1.0 to 10.0 mg/L
The dose should be individualized, depending upon the fish species and the degree of anesthesia required. Consideration should be taken when sedating or anesthetizing fish at water temperatures substantially different from the species preferred water temperature or at very low pH.
DURATION OF TREATMENT:
At doses suitable for total loss of equilibrium or anesthesia, do not expose fish for more than 60 min. At doses suitable to sedate fish for transportation, do not expose fish for more than 24 hr. To facilitate recovery upon removal from a solution of AquacalmTM, place fish in well oxygenated, high quality water free of AquacalmTM. Fish should recover in 20 to 90 min.
Use of AquacalmTM is contraindicated in species of fish that rely upon accessory air breathing organs for oxygen consumption. Sedation or anesthesia of such species may result in unacceptable rates of mortality.
The dose is based on the volume of water in which fish will be placed or held.
For example, if the desired AquacalmTM concentration is 2.0 mg/L and the tank holding the fish contains 10 L of water, use the following calculation:
2 mg/L X 10L = 20 mg = 0.02 g AquacalmTM
For example, if the desired AquacalmTM concentration is 2.0 mg/L and the tank holding the fish contains 5 gal of water, use the following calculation (note that the correction factor is used when volume is reported in gallons):
2 mg/L X 5 gal X 0.00378 = 0.038 g AquacalmTM
CAUTION AND WARNING
STORAGE AND HANDLING
Store at 10°C to 30°C (50°F to 86°F) and protect from sunlight or sources of heat.
Revised: 10/2010 Western Chemical Inc.
Reproduced with permission of U.S. National Library of Medicine
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